Azafulvenes 8. Cycloaddition Reaction of 8-Azaheptafulvene to Sulfene

1,3-Dipolar Cycloaddition Reaction of Nitrile Oxides to Isatin Imines

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Synthesis of (+)-8-deoxyvernolepin and its 11,13-dihydroderivative. A novel reaction initiated by sulfene elimination leads to the 2-Oxa-cis-decalin skeleton.

The title compounds are interesting candidates for antifungal screening. This paper describes the enantiospecific synthesis of these compounds starting from (+)-costunolide isolated from a commercially available extract. We used two novel reactions as key synthetic steps in this work: the acid-induced cyclization of an delta,epsilon-epoxy ester, which stereoselectively gave a hydroxymethyl-subs...

7 Be ( p , γ ) 8 B reaction

PREPARATION OF (CHLOROCARBONYL) PHENYLKETENB AND ITS CYCLOADDITION REACTION WITH BENZALDEHYDEV

Meldrum's acid, 2'5-diphenyl-1'3-dioxane-4'6-dione, was produced by [2+2] cycloadditions of the (chlorocarbony1)phenylketene with benzaldehyde. Acid hydrolysis of the meldrum's acid regenerated benzaldehyde and also yielded phenylacetic acid as the final product

Peroxynitrite reaction products of 3',5'-di-O-acetyl-8-oxo-7, 8-dihydro-2'-deoxyguanosine.

Of the DNA bases, peroxynitrite (ONOO-) is most reactive toward 2'-deoxyguanosine (dGuo), but even more reactive with 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodGuo), requiring a 1,000-fold excess of dGuo to provide 50% protection against the reaction with 8-oxodGuo. Therefore, it seems reasonable that 8-oxodGuo is a potentially important target in DNA and that the structures of the reaction p...